标题：Tunable thermosensitive behavior of multiple responsive chitin作者：Ding, Fuyuan; Tang, Zheng; Ding, Beibei; Xiong, Yuan; Cai, Jie; Deng,Hongbing; Du, Yumin; Shi, Xiaowen

来源出版物：JOURNAL OF MATERIALS CHEMISTRY B 卷：2 期：20 页：3050-3056 DOI：10.1039/c4tb00067f 出版年：2014

摘要：Chitin can be dissolved and homogeneously functionalized in NaOH/urea aqueous solvent. Previously, we reported that chitin modified with acrylamide (AMC) possesses high water solubility and can undergo a solgel transition responding to pH and cationic ions. In this report, we further explored the thermosensitive behavior of this multiple responsive chitin. We showed that the sol-gel transition temperature of AMC can be facilely adjusted by the degree of substitution (DS), pH, polymer concentration and the presence of anions or cations. Importantly, AMC can form a hydrogel at 37 degrees C and return to solution at 4 degrees C by adjusting experimental parameters. We anticipate this multiple responsive chitin may have potential applications in injectable materials and smart drug delivery.

入藏号：WOS:000335225400010

文献类型：Article

语种：English

扩展关键词：PHASE-TRANSITION; BIOMEDICAL APPLICATIONS; HOFMEISTER SERIES; AQUEOUS-SOLUTION;DRUG-DELIVERY;POLYMERS;MACROMOLECULES;HYDROGEL; GEL; POLY(N-ISOPROPYLACRYLAMIDE)

通讯作者地址：Shi, Xiaowen; Wuhan Univ, Sch Resource & Environm Sci, Environm Biotechnol Key Lab, Wuhan 430079, Peoples R China.

电子邮件地址：shixwwhu@163.com

地址：

[Ding, Fuyuan; Tang, Zheng; Xiong, Yuan; Deng, Hongbing; Du, Yumin; Shi, Xiaowen] Wuhan Univ, Sch Resource & Environm Sci, Environm Biotechnol Key Lab, Wuhan 430079, Peoples R China.

[Ding, Beibei; Cai, Jie] Wuhan Univ, Dept Chem, Wuhan 430072, Peoples R China.

研究方向：Materials Science

ISSN：2050-750X