标题：Chitin-based fast responsive pH sensitive microspheres for controlled drug release作者：Shang, Yu; Ding, Fuyuan; Xiao, Ling; Deng, Hongbing; Du, Yumin; Shi,Xiaowen

来源出版物：CARBOHYDRATE POLYMERS 卷：102 页：413-418 DOI：10.1016/j.carbpol.2013.11.039 出版年：FEB 15 2014

摘要：Ionically crosslinked chitin microspheres were prepared by using electrostatic droplet method and the drug release from the microspheres was controlled by adjusting external pH. Specifically, chitin was dissolved in NaOH/urea solution at low temperature and functionalized with acrylamide moieties. Acrylamide-modified chitin microspheres with a diameter of 400-500 pan can be obtained at the voltage of 6 kV and the pump speed of 5 mL h(-1). The formed microspheres were ionically crosslinked with Fe3+ and then complexed with polycationic polysaccharide chitosan. The structure of the microspheres was characterized by FT IR, SEM, and EDS analyses. Besides, the drug release behavior of the microspheres exhibited a fast responsive and pH sensitive release of vancomycin. It took 30 h for complete release of vancomycin in pH 4.0 buffer and pH 1.2 HCl solution while a fast release (10 min) occurred in pH 7.4 buffer. The results showed that the microspheres could be used in drug delivery.

入藏号：WOS:000331779600052

文献类型：Article

语种：English

作者关键词：Chitin microsphere, Ionically crosslinked, Electrostatic droplet method, pH sensitive, Drug delivery

扩展关键词：CHEMICALLY-MODIFIED CHITIN; ANTIBACTERIAL ACTIVITY; AQUEOUS-SOLUTION; CHITOSAN; BEADS; SYSTEM; FILMS

通讯作者地址：Shi,Xiaowen; Wuhan Univ, Sch Resource & Environm Sci, Wuhan 430079, Peoples R China.

电子邮件地址：shixwwhu@163.com

地址：

[Shi, Xiaowen]Wuhan Univ, Sch Resource & Environm Sci, Wuhan 430079, Peoples R China.Wuhan Univ, Hubei Biomass Resource Chem & Environm Biotechnol, Wuhan 430079, Peoples R China.

研究方向：Chemistry; Polymer Science

ISSN：0144-8617