标题：Electrical Programming of Soft Matter: Using Temporally Varying Electrical Inputs To Spatially Control Self Assembly

作者： Yan, K (Yan, Kun); Liu, Y (Liu, Yi); Zhang, JT (Zhang, Jitao); Correa, SO (Correa, Santiago O.); Shang, W (Shang, Wu); Tsai, CC (Tsai, Cheng-Chieh); Bentley, WE (Bentley, William E.); Shen, J (Shen, Jana); Scarcelli, G (Scarcelli, Giuliano); Raub, CB (Raub, Christopher B.); Shi, XW (Shi, Xiao-Wen); Payne, GF (Payne, Gregory F.)

来源出版物：BIOMACROMOLECULES卷：19期：2 页码:364-373 DOI：10.1021/acs.biomac.7b01464 出版年： FEB 2018

摘要：The growing importance of hydrogels in translational medicine has stimulated the development of top-down fabrication methods, yet often these methods lack the capabilities to generate the complex matrix architectures observed in biology. Here we show that temporally varying electrical signals can cue a self-assembling polysaccharide to controllably form a hydrogel with complex internal patterns. Evidence from theory and experiment indicate that internal structure emerges through a subtle interplay between the electrical current that triggers self-assembly and the electrical potential (or electric field) that recruits and appears to orient the polysaccharide chains at the growing gel front. These studies demonstrate that short sequences (minutes) of low-power (similar to 1 V) electrical inputs can provide the program to guide self-assembly that yields hydrogels with stable, complex, and spatially varying structure and properties.

入藏号：WOS:000425193600010

文献类型：Article

语种：English

扩展关键词： MESENCHYMAL STEM-CELLS; WAVE-FRONT MODEL; REGENERATIVE MEDICINE; ARTICULAR-CARTILAGE; PATTERN-FORMATION; SQUID BEAKS; BONE-MARROW; HYDROGELS; CHITOSAN; MICROSCOPY

通讯作者地址：Shi, XW (reprint author), Wuhan Univ, Sch Resource & Environm Sci, Hubei Int Sci & Technol Cooperat Base Sustainable, Wuhan 430079, Hubei, Peoples R China.

Payne, GF (reprint author), Univ Maryland, Inst Biosci & Biotechnol Res, College Pk, MD 20742 USA.

Payne, GF (reprint author), Univ Maryland, Fischell Dept Bioengn, College Pk, MD 20742 USA.

电子邮件地址：shixwwhu@163.com; gpayne@umd.edu

地址：

[Yan, Kun; Shi, Xiao-Wen] Wuhan Univ, Sch Resource & Environm Sci, Hubei Int Sci & Technol Cooperat Base Sustainable, Wuhan 430079, Hubei, Peoples R China.

[Liu, Yi; Bentley, William E.; Payne, Gregory F.] Univ Maryland, Inst Biosci & Biotechnol Res, College Pk, MD 20742 USA.

[Liu, Yi; Zhang, Jitao; Shang, Wu; Bentley, William E.; Scarcelli, Giuliano; Payne, Gregory F.] Univ Maryland, Fischell Dept Bioengn, College Pk, MD 20742 USA.

[Correa, Santiago O.; Raub, Christopher B.] Catholic Univ Amer, Dept Biomed Engn, Washington, DC 20064 USA.

[Tsai, Cheng-Chieh; Shen, Jana] Univ Maryland, Sch Pharm, Dept Pharmaceut Sci, Baltimore, MD 21201 USA.

[Yan, Kun] Wuhan Text Univ, Coll Mat Sci & Engn, Wuhan 430200, Hubei, Peoples R China.

影响因子：5.246