标题：Perchlorate-induced oxidative stress in isolated liver mitochondria作者：Zhao, Xiaohu; Zhou, Peijiang; Chen, Xiu; Li, Xi; Ding, Ling

来源出版物：ECOTOXICOLOGY 卷：23 期：10 SI页：1846-1853 DOI：10.1007/s10646-014-1312-9 出版年：DEC 2014

摘要：As a new threat to environment all through the world, perchlorate (ClO4-) was predominantly a thyrotoxin, and its toxic manifestations in non-thyroid were also documented. To date, little is known about the effect of ClO4- on cell and organelle. To reveal the toxicity of ClO4- on living organism in-depth, mitochondria isolated from liver of Carassius auratus were incubated with different concentrations of ClO4-. The results demonstrated that ClO4--induced mitochondrial oxidative stress, and subsequently caused a gradual opening of permeability transition pore leading to mitochondrial swelling and lipid peroxidative membrane damage. ClO4- has a conspicuous inhibition of electron transport chain activity which largely correlated to complexes I and IV. The investigations clearly demonstrated the oxidative stress of ClO4- in mitochondria, may well reveal cytotoxic effects in vitro that merit further investigation.

入藏号：WOS:000345034000005

文献类型：Article

语种：English

作者关键词：Perchlorate, Oxidative stress, Liver, Mitochondria

扩展关键词：ELECTRON-TRANSPORT CHAIN; DNA-DAMAGE; RESPIRATORY-CHAIN; RAT-BRAIN; METABOLISM; EXPOSURE; MOSQUITOFISH; CARDIOLIPIN; INHIBITION; INDUCTION

通讯作者地址：Zhou, Peijiang; Wuhan Univ, Coll Resources & Environm Sci, Hubei Biomass Resource Chem & Environm Biotechnol, Wuhan 430072, Hubei, Peoples R China.

电子邮件地址：50654069@qq.com; 1048122875@qq.com; 461792563@qq.com; 464289956@qq.com; 1048122875@qq.com

地址：

[Zhao, Xiaohu; Zhou, Peijiang; Chen, Xiu; Li, Xi; Ding, Ling] Wuhan Univ, Coll Resources & Environm Sci, Hubei Biomass Resource Chem & Environm Biotechnol, Wuhan 430072, Hubei, Peoples R China.

[Zhao, Xiaohu] Huazhong Agr Univ, Microelement Res Ctr, Wuhan 430070, Peoples R China.

研究方向：Environmental Sciences & Ecology; Toxicology

ISSN：0963-9292

eISSN:1573-3017