标题: Electrical signals regulate the release of insulin from electrodeposited chitosan composite hydrogel: An in vitro and in vivo study

作者: Tong, J (Tong, Jun); Liu, HY (Liu, Hongyu); Qi, LH (Qi, Luhe); Deng, HB (Deng, Hongbing); Du, YM (Du, Yumin); Shi, XW (Shi, Xiaowen)

来源出版物: JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART B-APPLIED BIOMATERIALS DOI: 10.1002/jbm.b.35103 提前访问日期: MAY 2022

摘要: Electrical signal controlled drug release from polymeric drug delivery system provides an efficient way for accurate and demandable drug release. In this work, insulin was loaded on inorganic nanoplates (layered double hydroxides, LDHs) and coated on a copper wire by co-electrodeposition with chitosan. The formed structure in chitosan composite hydrogel entrapped insulin efficiently, which were proved by various techniques. In addition, the drug loaded chitosan composite hydrogel demonstrated good biocompatibility as suggested by cell attachment. In vitro drug release experiment showed fast responsive pulsed release of insulin by biasing electrical signals. The in vivo experiment in diabetic rats revealed controllable insulin release in plasma and stable decrease of blood glucose can be achieved by using appropriate electrical signal. In addition, HE staining suggested negligible effect to the tissue by electrical signals. This work suggests that the electrical signal controlled insulin release from chitosan composited hydrogel may be a promising administration route for insulin.

文献类型: Article; Early Access

作者关键词: chitosan; composite hydrogel; controlled drug release; electrodeposition

地址: [Tong, Jun; Liu, Hongyu; Qi, Luhe; Deng, Hongbing; Du, Yumin; Shi, Xiaowen] Wuhan Univ, Hubei Biomass Resource Chem & Environm Biotechnol, Hubei Engn Ctr Nat Polymers Based Med Mat, Sch Resource & Environm Sci,Hubei Int Sci & Techn, Wuhan 430079, Peoples R China.

通讯作者地址: Shi, XW (通讯作者)，Wuhan Univ, Hubei Biomass Resource Chem & Environm Biotechnol, Hubei Engn Ctr Nat Polymers Based Med Mat, Sch Resource & Environm Sci,Hubei Int Sci & Techn, Wuhan 430079, Peoples R China.

电子邮件地址: shixw@whu.edu.cn

影响因子：3.368